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Abstract Title:

Gastrodia remodels intestinal microflora to suppress inflammation in mice with early atherosclerosis.

Abstract Source:

Int Immunopharmacol. 2021 Jul ;96:107758. Epub 2021 May 24. PMID: 34162137

Abstract Author(s):

Fei-Yu Liu, Jing Wen, Jiong Hou, Si-Qi Zhang, Chun-Bin Sun, Luo-Chuan Zhou, Wen Yin, Wen-Lin Pang, Cui Wang, Yi Ying, Si-Si Han, Jin-Yuan Yan, Chen-Xi Li, Jia-Li Yuan, Hai-Jing Xing, Zhong-Shan Yang

Article Affiliation:

Fei-Yu Liu

Abstract:

Atherosclsis is a critical actuator causing cardiac-cerebral vascular disease with a complicated pathogeneon, refered to the disorders of intestinal flora and persistent inflammation. Gastrodin (4-(hydroxymethyl) phenyl-β-D- Glucopyranoside) is the most abundant glucoside extracted from the Gastrodiaelata, which is a traditional Chinese herbal medicine for cardiac-cerebral vascular disease, yet its mechanisms remain little known. In the present study, the gastrodia extract and gastrodin attenuate the lipid deposition and foam cells on the inner membrane of the inner membrane of the thoracic aorta in the early atherosclerosis mice. Blood lipid detection tips that TC and LDL-C were reduced in peripheral blood after treatment with the gastrodia extract and gastrodin. Furthermore, unordered gut microbes are remodeled in terms of bacterial diversity and abundance at family and genus level. Also, the intestinal mucosa damage and permeability were reversed, accompaniedwith the reducing of inflammatory cytokines. Our findings revealed that the functions of gastrodia extract and gastrodin in cardiac-cerebral vascular disease involved to rescued gut microbes and anti-inflammation may be the mechanismof remission lipid accumulation.

Study Type : Animal Study

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