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Abstract Title:

Gastroprotective effect of kefir on ulcer induced in irradiated rats.

Abstract Source:

J Photochem Photobiol B. 2015 Mar ;144:85-93. Epub 2015 Feb 18. PMID: 25728227

Abstract Author(s):

Hanan A Fahmy, Amel F M Ismail

Article Affiliation:

Hanan A Fahmy

Abstract:

The current study was designed to investigate the protective effect of kefir milk on ethanol-induced gastric ulcers inγ-irradiated rats. The results of the present study revealed that treatment with γ-irradiation and/or ethanol showed a significant increase in ulcers number, total acidity, peptic, H(+)K(+)ATPase, MMP-2 and MMP-9 activities and MDA level, which were accompanied by a significant decrease in the mucus content, the stomach GSH level, the GSH-Px activity and DNA damage. Pre-treatment with kefir milk exert significant improvement in all the tested parameters. Kefir milk exerts comparable effect to that of the antiulcer drug ranitidine. In conclusion, the present study revealed that oral administration of kefir milk prevents ethanol-induced gastric ulcer in γ-irradiated rats that could attribute to its antioxidant, anti-apoptotic and radio-protective activities.

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