Article Publish Status: FREE
Abstract Title:

Gestational Exposure to Bisphenol-A Affects the Function and Proteome Profile of F1 Spermatozoa in Adult Mice.

Abstract Source:

Environ Health Perspect. 2016 Jul 6. Epub 2016 Jul 6. PMID: 27384531

Abstract Author(s):

Md Saidur Rahman, Woo-Sung Kwon, Polash Chandra Karmakar, Sung-Jae Yoon, Buom-Yong Ryu, Myung-Geol Pang

Article Affiliation:

Md Saidur Rahman


BACKGROUND: Maternal exposure to the endocrine disruptor bisphenol-A (BPA) has been linked to offspring reproductive abnormalities. Exactly how BPA affects offspring fertility, however, remains poorly understood.

OBJECTIVES: The aim of the present study was to evaluate the effect of gestational BPA exposure on sperm function, fertility, and proteome profile of F1 spermatozoa in adult mice.

METHODS: Pregnant CD-1 mice (F0) were gavaged with BPA at three different doses (50μg, 5 mg, and 50 mg•kg bw(-1)•day(-1)), on embryonic days 7 to 14. We investigated function, fertility, and related processes of F1 spermatozoa at postnatal day 120. We also evaluated protein profiles of F1 spermatozoa as a manner to monitor their functional affiliation to diseases.

RESULTS: We found that BPA inhibited sperm count, motility parameters, and intracellular ATP levels in a dose-dependent manner. These effects appeared to be caused by reduced numbers of stage VIII seminiferous epithelium in testis and decreased protein kinase-A (PKA) activity and tyrosine phosphorylation in spermatozoa. We also found that BPA compromised average litter size. Proteins differentially expressed in spermatozoa from BPA treatment groups are known to play a critical role in ATP generation, oxidative stress response, fertility, and pathogenesis of several diseases.

CONCLUSIONS: Our study provides mechanistic support for the hypothesis that gestational exposure to BPA alters sperm function and fertility via down-regulation of tyrosine phosphorylation through a PKA-dependent mechanism. In addition, we anticipate that the BPA-induced changes in the sperm proteome might be partly responsible for the observed effects in spermatozoa.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021, Journal Articles copyright of original owners, MeSH copyright NLM.