Abstract Title:

Gastroprotective Effect of Ginger Rhizome (Zingiber officinale) Extract: Role of Gallic Acid and Cinnamic Acid in H+, K+-ATPase/H. pylori Inhibition and Anti-oxidative Mechanism.

Abstract Source:

Evid Based Complement Alternat Med. 2009 Jul 1. PMID: 19570992

Abstract Author(s):

Siddaraju M Nanjundaiah, Harish Nayaka Mysore Annaiah, Shylaja M Dharmesh

Abstract:

Zinger officinale has been used as a traditional source against gastric disturbances from time immemorial. The ulcer-preventive properties of aqueous extract of ginger rhizome (GRAE) belonging to the family Zingiberceae is reported in the present study. GRAE at 200 mg kg(-1) b.w. protected up to 86% and 77% for the swim stress-/ethanol stress-induced ulcers with an ulcer index (UI) of 50 +/- 4.0/46 +/- 4.0 respectively, similar to that of lansoprazole (80%) at 30 mg kg(-1) b.w. Increased H(+), K(+)-ATPase activity and thiobarbituric acid reactive substances (TBARS) were observed in ulcer-induced rats, while GRAE fed rats showed normalized levels and GRAE also normalized depleted/amplified anti-oxidant enzymes in swim stress and ethanol stress-induced animals. Gastric mucin damage was recovered up to 77% and 74% in swim stress and ethanol stress, respectively after GRAE treatment. GRAE also inhibited the growth of H. pylori with MIC of 300 +/- 38 mug and also possessed reducing power, free radical scavenging ability with an IC(50) of 6.8 +/- 0.4 mug ml(-1) gallic acid equivalent (GAE). DNA protection up to 90% at 0.4 microg was also observed. Toxicity studies indicated no lethal effects in rats fed up to 5 g kg(-1) b.w. Compositional analysis favored by determination of the efficacy of individual phenolic acids towards their potential ulcer-preventive ability revealed that between cinnamic (50%) and gallic (46%) phenolic acids, cinnamic acid appear to contribute to better H(+), K(+)-ATPase and Helicobacter pylori inhibitory activity, while gallic acid contributes significantly to anti-oxidant activity.

 
 

Print Options


This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.