Abstract Title:

Ginger: A novel strategy to battle cancer through modulating cell signalling pathways.

Abstract Source:

Curr Pharm Biotechnol. 2019 Jan 19. Epub 2019 Jan 19. PMID: 30659535

Abstract Author(s):

Ahmad Almatroudi, Mohammed A Alsahli, Faris Alrumaihi, Khaled S Allemailem, Arshad Husain Rahmani

Article Affiliation:

Ahmad Almatroudi


Numerous studies have been performed in understanding the development of cancer. Though, the mechanism of action of genes in the development of cancer remains to be explained. The current mode of treatment of cancer shows adverse effect on normal cells and also alter the cell signalling pathways. However, ginger and their active compound has fascinated research based on animal model and laboratories during past decade due to its potentiality in killing of cancer cells. Ginger is a mixture of various compound including gingerol, paradol, zingiberene and shogaol and such compound are main player in the diseases management. Most of health promoting effects of ginger and its active compound can be attributed to its antioxidant and anti-tumour activity. Besides, active compound of ginger has proven their role in cancer management through its modulatory effect on tumour suppressor genes, cell cycle, apoptosis, transcription factors, angiogenesis and growth factor. In this review, role of ginger and their active compound in the inhibition of cancer growth through modulating cell signalling pathways will be reviewed and discussed.

Study Type : Review

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