Abstract Title:

[Effects of Ginkgo biloba extract (EGB) on acute myocardial ischemia induced by isoproterenol in rats].

Abstract Source:

Zhongguo Zhong Yao Za Zhi. 2009 Apr;34(7):900-3. PMID: 19623992

Abstract Author(s):

Fuyun Ding, Yongqing Wang, Yun Liu, Weifeng Yao, Shuqin Yu, Guanglin Xu

Article Affiliation:

Nanjing Normal University, Nanjing 210046, China. dingfuyun123@163.com

Abstract:

OBJECTIVE: To investigate the therapeutic effects of Ginkgo biloba extract (EGb) in rats with acute myocardial injury induced by isoproterenol (ISO). METHOD: The rats, induced by Isoproterenol (4 mg x kg(-1) x d(-1), 10 d, sc), were divided into groups: sham, model, metoprolol (10 mg x kg(-1) x d(-1), 13 d, ig), EGb (100 mg x kg(-1) x d(-1), 13 d, ig). RESULT: The cardiac parameters of the Model group were compromised significantly in both systolic and diastolic function. Improvement in cardiac function by EGb was significant. In model groups, plasma activities of AST, LDH, CK, HBDH, CKMB and ventricular weight index (LV and RV/BW) were elevated significantly. With the treatment with EGb and metoprolol, the enzymes and ventricular weight index were significantly ameliorated. CONCLUSION: G. biloba extract was beneficial to cardiac performance by improving myocardium enzymes and cardiac function in isoproterenol induced myocardial injury in rats.

Study Type : Animal Study

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