Abstract Title:

Effects of the standardized Ginkgo biloba extract EGb 761® on neuroplasticity.

Abstract Source:

Int Psychogeriatr. 2012 Aug ;24 Suppl 1:S21-4. PMID: 22784424

Abstract Author(s):

Walter E Müller, Jeanine Heiser, Kristina Leuner

Article Affiliation:

Department of Pharmacology, Biocenter, Goethe-University, Frankfurt, Germany. pharmacolnat@em.uni-frankfurt.de

Abstract:

Neuroplasticity, the ability of synapses to undergo structural adaptations in response to functional demand or dysfunctions is increasingly impaired in aging and Alzheimer's disease. EGb761® has been shown in several preclinical reports to increase nearly all aspects of impaired neuroplasticity (long-term potentiation, spine density, neuritogenesis, neurogenesis). While all three fractions of constituents (ginkgolides, flavonoids, bilobalide) seem to be active, the flavonoids and specifically the aglycone isorhamnetin seem to be most relevant.

Study Type : Review

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