Abstract Title:

Effect of Ginkgo biloba extract on matrix metalloproteinase-3 expression in a rat model of chondrocyte injury.

Abstract Source:

Genet Mol Res. 2015 ;14(4):18280-6. Epub 2015 Dec 28. PMID: 26782475

Abstract Author(s):

J Z Zeng, L F Ma, H Meng, H M Yu, Y K Zhang, A Guo

Article Affiliation:

J Z Zeng

Abstract:

A rat model with cartilage chondrocyte injury was established using interleukin-1β (IL-1β) to investigate the effect of Ginkgo biloba extract (EGb) on matrix metalloproteinase-3 (MMP-3) expression. Rat chondrocytes were extracted and randomly divided into six groups: control group, IL-1β (model) group, IL-1β + dexamethasone group, and IL-1β + EGb group (both high and low dose groups). Reverse transcriptase polymerase chain reaction and enzyme-linked immunosorbent assay were used to detect MMP-3 expression. Compared to the MMP-3 mRNA level in the control group, MMP-3 mRNA level significantly increased in the model group (P<0.05). The application of dexamethasone or EGb significantly decreased the MMP-3 mRNA level (P<0.05). MMP-3 mRNA and protein levels decreased in the EGb-treated group, especially in the high-dose group, compared to those in the dexamethasone group (P<0.05). EGb may reduce MMP-3 production during IL-1β-induced chondrocyte damage and protect chondrocytes to some extent, with better efficacy at high doses.

Study Type : Animal Study, In Vitro Study

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