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Abstract Title:

Pretreatment Attenuates Myocardial Ischemia-Reperfusion Injury via mitoBK.

Abstract Source:

Am J Chin Med. 2019 Jul 21:1-17. Epub 2019 Jul 21. PMID: 31327236

Abstract Author(s):

Tonghua Li, Yuyang Zhang, Jianwei Tian, Lu Yang, Jianchang Wang

Article Affiliation:

Tonghua Li

Abstract:

extracts (EGb) alleviate myocardial ischemia/reperfusion (MI/R) injury. However, the underlying mechanisms have not yet been characterized. This study aimed to investigate whether activation of large-conductance Ca-activated Kchannels at the inner mitochondrial membrane (mitoBKof cardiomyocytes is involved inextract-mediated cardioprotection. Shuxuening injection (SXNI, 12.5ml/kg/d), a widely prescribed herbal medicine containingextracts in China, or vehicle, was administered to C57BL/6 mice via tail vein injection for one week prior to surgical procedures. The mitoBKblocker paxilline (PAX) (1ml/kg, 115 nM) was administered via tail vein injection 30min prior to the onset of ischemia. The mice were randomly divided into the following groups: Sham, MI/R, MI/R+SXNI, and MI/R+SXNI+PAX. MI/R was induced by ligating the left anterior descending coronary artery for 30min with subsequent reperfusion for 24h. SXNI pretreatment conferred cardioprotective effects against MI/R injury as evidenced by reduced infarct size, improved cardiac function, and improved mitochondrial function. However, these effects were abrogated by co-administration with PAX. In addition, activation of mitoBKbyextract EGb761 reduced hypoxia/reoxygenation (H/R)-induced cardiomyocyte injurythrough the inhibition of mitochondrial fragmentation, restoration of the mitochondrial membrane potential, decreased generation of superoxide, and inhibition of apoptosis which is associated with alleviating mitochondrial Caoverload. These results indicated thatextracts pretreatment protected against MI/R injury via activation of mitoBK.

Study Type : Animal Study

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