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Abstract Title:

Ginsenoside Rb1 exerts antiarrhythmic effects by inhibiting Iand Iin rabbit ventricular myocytes.

Abstract Source:

Sci Rep. 2019 Dec 31 ;9(1):20425. Epub 2019 Dec 31. PMID: 31892729

Abstract Author(s):

Zhipei Liu, Lv Song, Peipei Zhang, Zhenzhen Cao, Jie Hao, Youjia Tian, Antao Luo, Peihua Zhang, Jihua Ma

Article Affiliation:

Zhipei Liu

Abstract:

Ginsenoside Rb1 exerts its pharmacological action by regulating sodium, potassium and calcium ion channels in the membranes of nerve cells. These ion channels are also present in cardiomyocytes, but no studies have been reported to date regarding the effects of Rb1 on cardiac sodium currents (I), L-type calcium currents (I) and action potentials (APs). Additionally, the antiarrhythmic potential of Rb1 has not been assessed. In this study, we used a whole-cell patch clamp technique to assess the effect of Rb1 on these ion channels. The results showed that Rb1 inhibited Iand I, reduced the action potential amplitude (APA) and maximum upstroke velocity (V), and shortened the action potential duration (APD) in a concentration-dependent manner but had no effect on the inward rectifier potassium current (I), delayed rectifier potassium current (I) or resting membrane potential (RMP). We also designed a pathological model at the cellular and organ level to verify the role of Rb1. The results showed that Rb1 abolished high calcium-induced delayed afterdepolarizations (DADs), depressed the increase in intracellular calcium ([Ca]), relieved calcium overload and protected cardiomyocytes. Rb1 can also reduce the occurrence of ventricular premature beats (VPBs) and ventricular tachycardia (VT) in ischemia-reperfusion (I-R) injury.

Study Type : In Vitro Study

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