Abstract Title:

Ginsenoside Rd Inhibits the Metastasis of Colorectal Cancer via Epidermal Growth Factor Receptor Signaling Axis.

Abstract Source:

IUBMB Life. 2018 Dec 21. Epub 2018 Dec 21. PMID: 30576064

Abstract Author(s):

Lan Thi Hanh Phi, Ita Novita Sari, Yoseph Toni Wijaya, Kwang Seock Kim, Kichul Park, Art E Cho, Hyog Young Kwon

Article Affiliation:

Lan Thi Hanh Phi


Ginsenoside Rd is a saponin from ginseng and has been reported to have various biological activities. However, the effect of ginsenoside Rd on the metastasis of colorectal cancer (CRC) remains unknown. Here, we found that ginsenoside Rd decreased the colony-forming ability, migration, invasion, and wound-healing abilities of CRC cells, although it did not affect cell proliferation. In addition, using an inverse-docking assay, we found that ginsenoside Rd bound to epidermal growth factor receptor (EGFR) with a high binding affinity, inducing the downregulation of stemness- and epithelial-mesenchymal transition-related genes; these were partially rescued by either exogenous EGF treatment or ectopic expression of SOX2. Furthermore, ginsenoside Rd significantly decreased the number and size of tumor metastasis nodules in the livers, lungs, and kidneys of mouse model of metastasis.© 2018 IUBMB Life, 9999(9999):1-10, 2018.

Study Type : In Vitro Study

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