Effects of ginsenosides on regulatory T cell differentiation.
Food Sci Biotechnol. 2018 Feb ;27(1):227-232. Epub 2017 Nov 23. PMID: 30263744
Regulatory T cells (Treg cells) are a subpopulation of T cells defined as CD4Foxp3CD25. They mainly function as immunosuppressive T cells by downregulating the induction and proliferation of effector T cells, but also modulate the immune system by maintaining self-tolerance and preventing autoimmune disease. In this study, the regulatory roles of ginsenosides, one of the active components in ginseng,C. A. Meyer, in Treg cell differentiation were examined. The results demonstrated that ginsenoside Rd induced Treg differentiation by upregulating Foxp3 expression and increased the generation of TGF-β1, IL-10 and IL-35. The data suggest that ginsenoside Rd may be a potential immunomodulating agent or supplement that can be applied for transplantation and autoimmune disorders.