Abstract Title:

Ginsenoside Rg1 prevents acetaminophen-induced oxidative stress and apoptosis via Nrf2/ARE signaling pathway.

Abstract Source:

J Asian Nat Prod Res. 2019 Jan 4:1-16. Epub 2019 Jan 4. PMID: 30608002

Abstract Author(s):

Yan Gao, Shi-Feng Chu, Zhao Zhang, Qi-Di Ai, Cong-Yuan Xia, Hui-Yong Huang, Nai-Hong Chen

Article Affiliation:

Yan Gao


Inappropriate use of acetaminophen (APAP) can lead to morbidity and mortality secondary to hepatic necrosis. Ginsenoside Rg1 is a major active ingredient in processed Panax ginseng, which is proved to elicit biological effects. We hypothesized the beneficial effect of Rg1 on APAP-mediated hepatotoxicity was through Nrf2/ARE pathway. The study was conducted in cells and mice, comparing the actions of Rg1. Rg1 significantly improved cell survival rates and promoted the expression of antioxidant proteins. Meanwhile, Rg1 reduced the excessive ROS and the occurrence of cell apoptosis, which were related to Nrf2/ARE pathway. Expression of Nrf2 has a certain cell specificity. [Formula: see text].

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