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Article Publish Status: FREE
Abstract Title:

The anxiolytic-like effects of ginsenoside Rg3 on chronic unpredictable stress in rats.

Abstract Source:

Sci Rep. 2018 May 17 ;8(1):7741. Epub 2018 May 17. PMID: 29773855

Abstract Author(s):

Jia-Ning Xu, Li-Fang Chen, Jun Su, Zhi-Li Liu, Jie Chen, Qing-Fen Lin, Wei-Dong Mao, Dong Shen

Article Affiliation:

Jia-Ning Xu

Abstract:

The present study is to evaluate the anxiolytic-like activities underlying ginsenoside Rg3 (GRg3). The anxiolytic-like activities were induced by GRg3 (20 and 40 mg/kg, i.g), evidenced by blocking the decreased time and entries in the open arms in elevated plus maze test and by reversing the increased latency to feed in novelty-suppressed feeding test. In addition, the decreased levels on progesterone, allopregnanolone, serotonin (5-HT) in the prefrontalcortex and hippocampus of chronic unpredictable stress (CUS) were blocked by GRg3 (20 and 40 mg/kg, i.g). Furthermore, the increased corticotropin releasing hormone, corticosterone and adrenocorticotropic hormone were blocked by GRg3 (20 and 40 mg/kg, i.g). Collectively, the anxiolytic-like effects produced by GRg3 were associated with the normalization of neurosteroids biosynthesis, serotonergic system as well as HPA axis dysfunction.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Anti-Anxiety Agents : CK(356) : AC(59)

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