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Article Publish Status: FREE
Abstract Title:

Ginsenoside-Rh2 Inhibits Proliferation and Induces Apoptosis of Human Gastric Cancer SGC-7901 Side Population Cells.

Abstract Source:

Asian Pac J Cancer Prev. 2016 ;17(4):1817-21. PMID: 27221858

Abstract Author(s):

Jun Qian, Jing Li, Jian-Guang Jia, Xin Jin, Da-Jun Yu, Chen-Xu Guo, Bo Xie, Li-Yu Qian

Article Affiliation:

Jun Qian

Abstract:

OBJECTIVES: To observed the effects of ginsenoside -Rh2 (GS-Rh2) on proliferation and apoptosis of side population (SP) human gastric cancer SGC-7901 cells.

MATERIALS AND METHODS: SGC-7901 SP and Non-SP cells were sorted by flow cytometry and assessed using the cck-8 method. Expression of apoptosis-related proteins Bax and Bcl-2 of SP before and after the intervention was determined by Western-blotting.

RESULTS: It was found that the proliferation of SP was significantly faster than that of NSP (<0.05). In addition, GS-Rh2 inhibited proliferation of gastric cancer SP cells, induced cell cycle arrest and cell apoptosis, and changed the expression of BAX/Bcl-2 proteins in a time-dependent and concentration-dependent manner (<0.05).

CONCLUSIONS: With increase of GS-Rh2 dose, GS-Rh2 gradually inhibit the proliferation of SGC-7901 SP cells, which have high proliferation rate, through G1/G0 phase arrest, followed by apoptosis which involves the up-regulation of Bax and the down-regulation of Bcl-2.

Study Type : In Vitro Study

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