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Abstract Title:

Ginsenoside Rh2 inhibits proliferation and induces apoptosis in human leukemia cells via TNF-α signaling pathway.

Abstract Source:

Acta Biochim Biophys Sin (Shanghai). 2016 Aug ;48(8):750-5. Epub 2016 May 13. PMID: 27177748

Abstract Author(s):

Jingjia Huang, Kunjian Peng, Linghao Wang, Bin Wen, Lin Zhou, Tiao Luo, Min Su, Jijia Li, Zhiyong Luo

Article Affiliation:

Jingjia Huang

Abstract:

Ginsenoside Rh2, a triterpene saponin extracted from Panax ginseng, exhibits pharmacological activity against multiple cancers. However, the anticancer mechanism of ginsenoside Rh2 is unclear. In this study, we found that ginsenoside Rh2 effectively inhibits growth and induces apoptosis of HL-60 cells. Using microarray technology, we found that tumor necrosis factor-α (TNF-α) is clearly up-regulated. Furthermore, anti-TNF-α antibody relieved the Rh2-induced HL-60 cell apoptosis via suppression of caspase-8, caspase-9, and caspase-3 activation. In addition, TNF-α up-regulation was also observed in other Rh2-treated cancer cell lines. These results demonstrate that TNF-α plays a key role in ginsenoside Rh2-induced cell apoptosis.

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Sayer Ji
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