Article Publish Status: FREE
Abstract Title:

Ginsenoside Rh2 reduces ischemic brain injury in rats.

Abstract Source:

Biol Pharm Bull. 2004 Mar ;27(3):433-6. PMID: 14993818

Abstract Author(s):

Eun-Kyung Park, Min-Kyung Choo, Jin Kyung Oh, Jong Hoon Ryu, Dong-Hyun Kim

Article Affiliation:

Eun-Kyung Park


Ginseng was incubated under mildly acidic conditions and its inhibitory effect on a rat ischemia-reperfusion model was investigated. When ginseng was treated with 0.1% hydrochloric acid at 60 degrees C, its protopanaxadiol saponins were transformed to diasteromeric ginsenoside Rg3 and Delta20-ginsenoside Rg3. When the transformed ginseng extract, of which the main component was ginsenosides Rg3, was treated with human intestinal microflora, the main metabolite was ginsenoside Rh2. Orally administered acid-treated ginseng (AG) extract and ginsenoside Rh2 potently protect ischemia-reperfusion brain injury. The ginsenoside Rh2 also inhibited prostaglandin-E2 synthesis in lipopolysaccharide-stimulated RAW264.7 cells, but showed no in vitro antioxidant activity. These results suggest that AG and ginsenoside Rh2 can improve ischemic brain injury.

Study Type : Animal Study

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