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Article Publish Status: FREE
Abstract Title:

Inhibitory Effects of Ginsenoside Ro on the Growth of B16F10 Melanoma via Its Metabolites.

Abstract Source:

Molecules. 2019 Aug 17 ;24(16). Epub 2019 Aug 17. PMID: 31426477

Abstract Author(s):

Si-Wen Zheng, Sheng-Yuan Xiao, Jia Wang, Wei Hou, Ying-Ping Wang

Article Affiliation:

Si-Wen Zheng

Abstract:

Ginsenoside Ro (Ro), a major saponin derived and isolated fromC.A. Meyer, exerts multiple biological activities. However, the anti-tumour efficacy of Ro remains unclear because of its poor in vitro effects. In this study, we confirmed that Ro has no anti-tumour activity in vitro. We explored the anti-tumour activity of Ro in vivo in B16F10 tumour-bearing mice. The results revealed that Ro considerably suppressed tumour growth with no significant side effects on immune organs and body weight. Zingibroside R1, chikusetsusaponin IVa, and calenduloside E, three metabolites of Ro, were detected in the plasma of Ro-treated tumour-bearing mice and showed excellent anti-tumour effects as well as anti-angiogenic activity. The results suggest that the metabolites play important roles in the anti-tumour efficacy of Ro in vivo. Additionally, the haemolysis test demonstrated that Ro has good biocompatibility. Taken together, the findings of this study demonstrate that Ro markedly suppresses the tumour growth of B16F10-transplanted tumours in vivo, and its anti-tumour effects are based on the biological activity of its metabolites. The anti-tumour efficacy of these metabolites is due, at least in part, to its anti-angiogenic activity.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Antiproliferative : CK(4773) : AC(3450)

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