Abstract Title:

Anti-angiogenic potential of Gleditsia sinensis fruit extract.

Abstract Source:

Int J Mol Med. 2003 Aug;12(2):269-73. PMID: 12851730

Abstract Author(s):

Larry Ming Cheung Chow, Chung Hin Chui, Johnny Cheuk On Tang, Fung Yi Lau, Mabel Yin Chun Yau, Gregory Yin Ming Cheng, Raymond Siu Ming Wong, Paul Bo San Lai, Thomas Wai Tong Leung, Ivy Tuang Ngo Teo, Filly Cheung, Dean Guo, Albert Sun Chi Chan

Abstract:

Blood supply plays a crucial role in solid tumour development and leukaemogenesis. It has been suggested that blocking of angiogenesis could be possible in cancer therapy. We have demonstrated the antiproliferative activity of Gleditsia sinensis fruit extract (GSE) on various human solid tumour cancer cell lines as well as leukaemia cell lines and primary cultured leukaemia cells obtained from leukaemia patients. However, the antiangiogenic potential of GSE has not been demonstrated. Here we demonstrated that GSE could reduce vascular endothelial growth factor (VEGF) mRNA expression in dose- and time course-dependently in MDA-MB231 breast cancer and HepG2 hepatoblastoma cell lines as measured by reverse transcriptase polymerase chain reaction. Enzyme-linked immunosorbent assay further showed that GSE could reduce the VEGF secretion from various cancer cell lines including MDA-MB231, HepG2, HL-60 (acute promyelocytic leukaemia) and eleven primary cultured leukaemia cells obtained from acute myelogenous leukaemia patients. In vivo chick chorioallantoic membrane assay illustrated that GSE could reduce the angiogenic activity of basic fibroblast growth factor. Taken together, the information suggested that GSE could be potentially used as an angiogenic inhibitor in both solid tumour and leukaemia therapy.

Study Type : Animal Study

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Sayer Ji
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