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Abstract Title:

Findings in normal rats following administration of gliadorphin-7 (GD-7).

Abstract Source:

Peptides. 2003 Feb;24(2):321-3. PMID: 12668219

Abstract Author(s):

Zhongjie Sun, Robert Cade

Article Affiliation:

Departments of Medicine and Physiology, University of Florida, HSC, 32610-0204, Gainesville, FL, USA.

Abstract:

This paper discusses the effects of gliadorphin-7 (GD-7) infusion in rats and contrasts them with those of beta-casomorphin-7 (betaC-7). Both induce FLI in a dose related fashion. Very strong expression in both geniculate nuclei (GN) and the alveus hippocampus follow GD-7 400 microgram and betaC-7 30 microgram/kg BW. GD-7 affects only these three regions while betaC-7affects 45. FLI is prevented by Naloxone 2mg/kg BW in all regions except the GN where it is diminished 60%. betaC-7 causes bizarre behavior beginning 60s after infusion is started. GD-7 causes no behavioral change. These findings suggest GD-7 gains access to brain cells by diffusion through circumventricular organs while betaC-7 passes the BBB by carrier facilitation.

Study Type : Animal Study

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Sayer Ji
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