Abstract Title:

Oxytocic properties of the aqueous extract of Globimetula braunii (loranthaceae).

Abstract Source:

Pharmacology. 2006;76(2):69-75. Epub 2005 Nov 11. PMID: 18930855

Abstract Author(s):

Oboh Ie, Nworgu Zam

Article Affiliation:

Department of Pharmacognosy and Department of Pharmacology, Faculty of Pharmacy, University of Benin, PMB 1154, Benin City, Nigeria. emakhuoboh@yahoo.co.uk

Abstract:

The leaves of Globimetula braunii are used in ethnomedicine to augment labour. The crude aqueous extract of the plant was tested on isolated rat uteri. The agonistic activity of the aqueous extract was compared with that of a standard uterine stimulant oxytocin and uterine smooth muscle antagonists atropine and salbutamol. The extract was found to exhibit oxytocic activity on the uterine smooth muscle which was less potent than that of oxytocin. The force of contraction (3.60 +/-0.25 g) elicited by the highest concentration of the extract (640 mg/ ml) was similar to that of 2.7 x 10-4 mg / ml of oxytocin (3.61+/-0.17 g). Oxytocin was also observed to significantly (p<0.05) enhance the uterine contractile effect of the extract. The oxytocic effects of the extract was significantly (p<0.05) inhibited by both atropine and salbutamol. The oxytocic effects indicate the presence of active principle(s) which would explain the use of the leaves of Globimetula braunii to "hasten delivery" in traditional medicine practice.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.