Glutathione inhibits trace metal-induced prophyrias. - GreenMedInfo Summary
Attenuation of porphyrinogen oxidation by glutathione in vitro and reversal by porphyrinogenic trace metals.
Biochem Biophys Res Commun. 1988 May 16;152(3):1428-34. PMID: 3132158
We have employed a model in vitro system for iron-peroxide-catalyzed oxidation of porphyrinogens to investigate the potential role of glutathione (GSH) in trace metal-induced porphyrias. GSH strongly attenuates porphyrinogen oxidation at biologically relevant concentrations in a dose-dependent manner. Porphyrinogenic trace metals reduce the effectiveness of GSH as a porphyrinogen antioxidant, leading to significantly higher rates of porphyrinogen oxidation to porphyrins. These observations may, in part, underlie the etiology of porphyrinurias induced during prolonged trace metal exposures.