Gluten sensitivity is associated with sporadic cerebellar ataxia in Taiwan. - GreenMedInfo Summary
Gluten sensitivity: associated sporadic cerebellar ataxia in Taiwan.
Acta Neurol Taiwan. 2010 Dec;19(4):263-9. PMID: 21210327
Department of Vascular and Genomic Center, Changhua Christian Hospital.
Purpose: Gluten sensitivity (GS) is related to the pathogenesis of sporadic or hereditary ataxia. Methods: Total of 194 healthy controls and patients with either hereditary ataxia (n=207) or sporadic ataxia (n=361) were tested for the circulating gluten-related autoantibodies which serve as biomarkers to interpret the existence of GS. Results: The incidences of GS in each population were 1% in normal subjects, 2% in hereditary ataxia patients and 9% in sporadic ataxia patients. High serum level of anti-gliadin IgG/IgA and t-transglutaminase IgA were disclosed at the sporadic ataxia patients compared with normal subjects. However, the anti-gliadin IgG is more specific to the disease of sporadic ataxia. Conclusion: Relatively higher incidence of GS was found in the population of sporadic ataxia patients but not in either normal subjects or hereditary ataxia patients in Taiwan. Anti-gliadin IgG still is a very powerful indicator to implicate the immune-related sporadic ataxia and we conclude that GS-related sporadic ataxia exists in Taiwan with linkage to autoimmune events.