Abstract Title:

Quantification and bio-assay ofα-glucosidase inhibitors from the roots of Glycyrrhiza uralensis Fisch.

Abstract Source:

Nat Prod Res. 2015 Dec 14:1-5. Epub 2015 Dec 14. PMID: 26653365

Abstract Author(s):

San-Hu Gou, Jie Liu, Miao He, Yin Qiang, Jing-Man Ni

Article Affiliation:

San-Hu Gou


This work aimed to investigate theα-glucosidase inhibitor from the roots of Glycyrrhiza uralensis Fisch. Seven flavonoids were isolated, and the total content of compounds 1-7 were more than 50% in Glycyrrhiza total flavones (GTF), and the content of compound 1 and 2 was abundant in GTF. The results of the α-glucosidase inhibitoryactivities indicated that compounds 1-6 and GTF respectively with the IC50 values of 31.303, 30.263, 23.363, 19.528, 10.854, 26.454 and 21.641 μg/mL exhibited the more potent activity than acarbose with the IC50 values of 38.995 μg/mL. These result suggested that Glycyrrhiza flavonoids may become a valid alternative of potential basis for new hypoglycaemic and antidiabetic agents.

Study Type : In Vitro Study

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