Article Publish Status: FREE
Abstract Title:

Glycyrrhizin alleviates non-alcoholic steatohepatitis via modulating bile acids and meta-inflammation.

Abstract Source:

Drug Metab Dispos. 2018 Jun 29. Epub 2018 Jun 29. PMID: 29959134

Abstract Author(s):

Tingting Yan, Hong Wang, Lijuan Cao, Qiong Wang, Shogo Takahashi, Tomoki Yagai, Guolin Li, Kristopher W Krausz, Guangji Wang, Frank J Gonzalez, Haiping Hao

Article Affiliation:

Tingting Yan


Non-alcoholic steatohepatitis (NASH) is the progressive stage of non-alcoholic fatty liver disease that may ultimately lead to cirrhosis and liver cancer, and there are few therapeutic options for its treatment. Glycyrrhizin (GL), extracted from the traditional Chinese medicine (TCM) liquorice, has potent hepatoprotective effects in both preclinical animal models and in humans. However, little is known about its effects and mechanisms in treating NASH. To explore the effects of GL on NASH, GL or its active metabolite glycyrrhetinic acid (GA), was administered to mice treated with a methionine-choline-deficient (MCD) diet-induced NASH model, and histological and biochemical analyses used to measure the degree of lipid disruption, liver inflammation and fibrosis. GL significantly improved MCD diet-induced hepatic steatosis, inflammation and fibrosis, and inhibited activation of the NLR family pyrin domain-containing 3 (NLRP3) inflammasome. GL significantly attenuated serum bile acids accumulation in MCD diet-fed mice partially by restoring inflammation-mediated hepatic farnesoid X receptor (FXR) inhibition. In Raw 264.7 macrophage cells, both GL and GA inhibited deoxycholic acid-induced NLRP3 inflammasome-associated inflammation. Notably, both intraperitoneal injection of GL's active metabolite GA, and oral administration of GL, prevented NASH in mice, indicating that GL may attenuate NASH via its active metabolite GA. These results reveal that GL, via restoring bile acids homeostasis and inhibiting inflammatory injury, can be a therapeutic option for treatment of NASH.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.