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Article Publish Status: FREE
Abstract Title:

Glycyrrhizin Suppresses the Growth of Human NSCLC Cell Line HCC827 by Downregulating HMGB1 Level.

Abstract Source:

Biomed Res Int. 2018 ;2018:6916797. Epub 2018 Jan 15. PMID: 29568761

Abstract Author(s):

Xiaojin Wu, Weitao Wang, Yuanyuan Chen, Xiangqun Liu, Jindong Wang, Xiaobin Qin, Dawei Yuan, Tao Yu, Guangxia Chen, Yanyan Mi, Jie Mou, Jinpeng Cui, Ankang Hu, Yunxiang E, Dongsheng Pei

Article Affiliation:

Xiaojin Wu

Abstract:

Lung cancer has very high mortality and glycyrrhizin was found to significantly inhibit the growth of lung cancer cellsand tissues in mice. However, the detailed inhibitory role of glycyrrhizin in the growth of lung cancer is still unclear. In this study, we first found that glycyrrhizin inhibited the growth of lung tumor in PDX mice. And high level of HMGB1 promoted the migration and invasion of lung cancer cells, which was suppressed by glycyrrhizin. Moreover, glycyrrhizin reduced the activity of JAK/STAT signaling pathway, which is the upstream regulator of HMGB1. Therefore, this study revealed a potential mechanism by which glycyrrhizin can inhibit the progression of lung cancer.

Study Type : In Vitro Study

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