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Article Publish Status: FREE
Abstract Title:

Acute Intake of a Grape and Blueberry Polyphenol-Rich Extract Ameliorates Cognitive Performance in Healthy Young Adults During a Sustained Cognitive Effort.

Abstract Source:

Antioxidants (Basel). 2019 Dec 17 ;8(12). Epub 2019 Dec 17. PMID: 31861125

Abstract Author(s):

Pierre Philip, Patricia Sagaspe, Jacques Taillard, Claire Mandon, Joël Constans, Line Pourtau, Camille Pouchieu, Donato Angelino, Pedro Mena, Daniela Martini, Daniele Del Rio, David Vauzour

Article Affiliation:

Pierre Philip

Abstract:

Despite an increasing level of evidence supporting the individual beneficial effect of polyphenols on cognitive performance, information related to the potential synergistic action of these phytonutrients on cognitive performance during a prolonged cognitive effort is currently lacking. This study investigated the acute and sustained action of a polyphenols-rich extract from grape and blueberry (PEGB), on working memory and attention in healthy students during a prolonged and intensive cognitive effort. In this randomised, cross-over, double blind study, 30 healthy students consumed 600 mg of PEGB or a placebo. Ninety minutes after product intake, cognitive functions were assessed for one hour using a cognitive demand battery including serial subtraction tasks, a rapid visual information processing (RVIP) task and a visual analogical scale. Flow-mediated dilation (FMD) and plasma flavan-3-ols metabolites quantification were also performed. A 2.5-fold increase in serial three subtraction variation net scores was observed following PEGB consumption versus placebo (<0.001). A trend towards significance was also observed with RVIP percentage of correct answers (= 0.058). No treatment effect was observed on FMD. Our findings suggest that consumption of PEGB coupled with a healthy lifestyle may be a safe alternative to acutely improve working memory and attention during a sustained cognitive effort.

Study Type : Human Study

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