Abstract Title:

Grape juice concentrate (G8000™) modulates apoptosis but not oxidative stress following rat colon carcinogenesis induced by azoxymethane.

Abstract Source:

Toxicol Mech Methods. 2015 Feb ;25(2):91-7. Epub 2015 Jan 22. PMID: 25421551

Abstract Author(s):

Celina Tizuko Fujiyama Oshima, Gilles Landman, Ana Paula Ribeiro Paiotti, Ricardo Artigiani Neto, Roseane Mendes Silva, Vanessa Maria De Lima Pazine Campanholo, Andrea Pittelli Boiago Gollucke, Daniel Araki Ribeiro, Nora Manoukian Forones

Article Affiliation:

Celina Tizuko Fujiyama Oshima


OBJECTIVES: The aim of this study was to evaluate if grape juice concentrate is able to protect against experimental colon carcinogenesis.

MATERIAL AND METHODS: For this purpose, a total of 35 male Wistar rats were randomly distributed into seven groups: G1: SHAM animals receiving only saline; G2: animals receiving 15 mg/kg azoxymethane (AOM); G3: animals receiving 1% grape juice concentrate 2 weeks before the administration of AOM; G4: animals receiving 2% grape juice concentrate 2 weeks before the administration of AOM; G5: animals receiving 1% grape juice concentrate 4 weeks after the last administration ofAOM; G6: animals receiving 2% grape juice concentrate 4 weeks after the last administration of AOM; G7: animals receiving only 2% grape juice concentrate.

RESULTS: The group that received 2% grape juice concentrate before induction with AOM showed the decreased expression of Bcl-2 compared to those animals that were induced by AOM (positive control). Regarding Bax, animals that received grape juice at 2% decreased Bax immunoexpression when compared to AOM group. Furthermore, animals that intake grape juice at 1% after induced by AOM decreased Bax immunoexpression as well. 8-OHdGLI did not show significant statistically differences (p > 0.05) among groups.

CONCLUSION: In summary, our results demonstrate that grape juice is able to modulate rat colon carcinogenesis as a result of induction of apoptosis.

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Sayer Ji
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