Article Publish Status: FREE
Abstract Title:

Grape seed and skin extract alleviates high-fat diet-induced renal lipotoxicity and prevents copper depletion in rat.

Abstract Source:

Appl Physiol Nutr Metab. 2013 Mar ;38(3):259-67. Epub 2013 Jan 7. PMID: 23537016

Abstract Author(s):

Kamel Charradi, Salem Elkahoui, Ines Karkouch, Ferid Limam, Ghaith Hamdaoui, Fethy Ben Hassine, Michèle Veronique El May, Ahmed El May, Ezzedine Aouani

Article Affiliation:

Kamel Charradi


Obesity is a public health problem that contributes to morbidity and mortality from diabetes, heart disease, stroke, and cancers. The purpose of this investigation was to analyse the link between obesity-induced oxidative stress, renal steatosis, and kidney dysfunction, as well as the protective effect of grape seed and skin extract. Rats were fed a standard diet or a high-fat diet for 6 weeks and were either treated or not treated with grape seed and skin extract. Fat-induced oxidative stress was evaluated in the kidney with a special emphasis on transition metals. High-fat diet induced triglyceride deposition and disturbances in kidney function parameters, which are linked to an oxidative stress status and depletion of copper from the kidney. Grape seed and skin extract abrogated almost all fat-induced kidney disturbances. Grape seed and skin extract exerted potential protection against fat-induced kidney lipotoxicity and should find potential application in other kidney-related diseases.

Study Type : Animal Study

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