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Abstract Title:

Grape Seed Procyanidin Extract Reduces Arsenic-Induced Renal Inflammatory Injury in Male Mice.

Abstract Source:

Biomed Environ Sci. 2017 Jul ;30(7):535-539. PMID: 28756814

Abstract Author(s):

Cheng Wang, Jun Li, Guan Ling Song, Qiang Niu, Shang Zhi Xu, Gang Ling Feng, Hai Xia Wang, Yu Li, Shu Gang Li, Feng Li

Article Affiliation:

Cheng Wang

Abstract:

The aim of the present study is to evaluate the ability and mechanism by which grape seed procyanidin extract (GSPE) relieves arsenic trioxide (As2O3)-induced renal inflammatory injury. Therefore, male Kunming mice were treated with As2O3 and/or GSPE by gavage for 5 weeks. Mice were then sacrificed and inflammatory cytokines of kidneys were examined by ELISA, whereas the expression levels of molecules involved in the nuclear factor (NF)-κB signaling pathway were evaluated by both qRT-PCR and Western blot. Our results indicate that GSPE prevents As2O3-mediated renal inflammatory injury by inhibiting activation of the NF-κB signaling pathway and inflammatory cytokine production, while promoting expression of anti-inflammatory cytokines.

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Sayer Ji
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