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Abstract Title:

Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats.

Abstract Source:

BMC Res Notes. 2020 Apr 10 ;13(1):208. Epub 2020 Apr 10. PMID: 32276657

Abstract Author(s):

Cimi Ilmiawati, Fajar Fitri, Zelly Dia Rofinda, Mohamad Reza

Article Affiliation:

Cimi Ilmiawati

Abstract:

OBJECTIVE: Currently, there are many efforts to find functional nutrients for obesity management, and the green coffee extract is a potential candidate. This study aimed to examine the effect of low dose administration of  green coffee extract on body weight, serum lipids, and TNF-α level in high-fat diet-induced obese rats.

RESULTS: Administration of green coffee extract to high-fat diet-induced obese male Wistar rats (Rattus norvegicus) reduced body weight, total serum cholesterol, and triglyceride at the dose of 10, 20, and 40 mg/kg BW/day; lowered serum LDL-cholesterol at the treatment dose of 20 mg/kg BW/day (p < 0.05). The effective dose to decrease serum TNF-α level was 40 mg/kg BW/day, while the effective dose to improve the lipid profile was 10 mg/kg BW/day. These results support the potential use of green coffee extract as a functional nutrient in the management of obesity.

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