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Abstract Title:

Clinical efficacy and safety of Lyprinol, a patented extract from New Zealand green-lipped mussel (Perna Canaliculus) in patients with osteoarthritis of the hip and knee: a multicenter 2-month clinical trial.

Abstract Source:

Eur Ann Allergy Clin Immunol. 2003 Jun;35(6):212-6. PMID: 12872680

Abstract Author(s):

Se Haeng Cho, Young Bok Jung, Sang Cheol Seong, Hyung Bin Park, Ki Yong Byun, Dong Chul Lee, Eun Kyoo Song, Jung Hwan Son

Article Affiliation:

Yonsei Medical Clinic, Seoul, Korea.

Abstract:

OBJECTIVE: To validate the clinical efficacy and safety of Lyprinol (a patented extract from Perna Canaliculus), a 5-LOX inhibitor in patients with osteoarthritis.

METHODS: In this multicenter trial, 60 patients with symptomatic osteoarthritis of the knee and hip were included to receive Lyprinol at a dose of 2 capsules twice a day. After a 4- and 8-week treatment period, the following parameters were analyzed: visual analogue scale; Lequesne functional index; global assessment by patients; global assessment by physician; and adverse effects.

RESULTS: Lyprinol treatment led to significant improvement of the signs and symptoms of osteoarthritis as determined by all efficacy measures. After a 4- and 8-week treatment period, 53% and 80% (respectively) of patients experienced significant pain relief, and improvement of joint function. There was no reported adverse effect during this clinical trial.

CONCLUSION: Lyprinol was very effective and is a promising anti-inflammatory product that relieves the signs and symptoms of osteoarthritis, without adverse effect.

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Sayer Ji
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