Article Publish Status: FREE
Abstract Title:

Green satsuma mandarin orange () extract reduces adiposity and induces uncoupling protein expression in skeletal muscle of obese mice.

Abstract Source:

Food Sci Biotechnol. 2019 Jun ;28(3):873-879. Epub 2018 Nov 2. PMID: 31093446

Abstract Author(s):

Jeong Kee Kim, Hyun Woo Jeong, A Young Kim, Yong Deog Hong, Ji Hae Lee, Jin Kyu Choi, Jae Sung Hwang

Article Affiliation:

Jeong Kee Kim


Increased fat mass, which is induced by the storage of excess nutrients, is considered a causal factor for various metabolic disorders, including insulin resistance, type 2 diabetes, hyperlipidemia, hyperglycemia, hypertension, atherosclerosis, and non-alcoholic fatty liver disease. Therefore, it is necessary to prevent hyperadiposity to sustain a healthy life. Recently, uncoupling proteins (UCPs) were suggested to be molecular targets for curing obesity and its complications. In this study, green satsuma mandarin orange () extract (GME) increased UCP3 expression in cultured myocytes. In a diet-induced obese animal model, administration of GME reduced fat mass and average fat cell size. Similar to in vitro experiments, GME restored expression of UCP3 in skeletal muscle. Moreover, GME also induced UCP2 expression in skeletal muscle. In conclusion, GME is suggested to be a novel functional dietary supplement for adiposity control through induction of UCPs.

Study Type : Animal Study

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Sayer Ji
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