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Abstract Title:

Green tea: A possibility in the therapeutic approach of inflammatory bowel diseases?: Green tea and inflammatory bowel diseases.

Abstract Source:

Complement Ther Med. 2019 Apr ;43:148-153. Epub 2019 Jan 19. PMID: 30935522

Abstract Author(s):

Sandra Maria Barbalho, Henrique Bosso, Letícia M Salzedas-Pescinini, Ricardo de Alvares Goulart

Article Affiliation:

Sandra Maria Barbalho

Abstract:

OBJECTIVE: this review aimed to investigate the effects of green tea polyphenols (GTP) in Ulcerative colitis and Crohn´s Disease.

MATERIALS AND METHODS: The databases used were MEDLINE-and EMBASE (October 2009 to September 2018). Studies that reported the use of green tea and its effects on IBD were included.

RESULTS: Ten articles were included in this review.

DISCUSSION: GTP play a role in reducing TNF-α, Interleukin 1β (IL-1β), IL-6, IL-8, and 17; downregulate cyclooxygenase-mediated I kappa B kinase and transcription of NFκB. They regulate the pathways mediated by the Nuclear erythroid 2-related factor 2, mitogen-activated protein kinases, and signal transducer and the activator of transcription 1/3, and also minimize the lipid peroxidation. Furthermore, GTP can stimulate antioxidant enzymes. These actions reduce inflammatory and oxidant patterns in IBD resulting in improvement of the disease scores.

CONCLUSIONS: We suggest that professionals and researchers take into account the use of GTP in further researches and in clinical practice in order to verify the real effects in humans.

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