Abstract Title:

Green tea epigallocatechin-3-gallate attenuates Porphyromonas gingivalis-induced atherosclerosis.

Abstract Source:

FEMS Immunol Med Microbiol. 2012 Sep 11. Epub 2012 Sep 11. PMID: 22966806

Abstract Author(s):

Yu Cai, Tomoko Kurita-Ochiai, Tomomi Hashizume, Masafumi Yamamoto

Article Affiliation:

Department of Microbiology and Immunology, Nihon University, School of Dentistry at Matsudo, Chiba, Japan.

Abstract:

The purpose of this study was to determine whether epigallocatechin-3-gallate (EGCG) ameliorates Porphyromonas gingivalis-induced atherosclerosis. P. gingivalis was shown to accelerate atheroma formation in a murine model, and EGCG is a polyphenol extract from green tea with health benefits. Apolipoprotein E knockout mice were administered EGCG or vehicle in drinking water; then they were fed high fat diets and injected with P. gingivalis three times a week for 3 weeks. Mice were then killed at 15 weeks. Atherosclerotic plaques in the proximal aorta were determined by Oil Red O staining. Atherosclerosis risk factors in serum, liver, or aorta were analyzed using cytokine antibody arrays, ELISA, and real-time PCR. Atherosclerotic lesion areas of the aortic sinus caused by P. gingivalis infection decreased in EGCG-treated groups, wherein EGCG reduced the production of C-reactive protein, MCP-1, and oxidized LDL, and slightly lowered LDL/VLDL cholesterol in P. gingivalis-challenged mice serum. Furthermore, the increase in CCL2, MMP-9, ICAM-1, HSP60, CD44, LOX-1, NOX-4, p22phox, and iNOS gene expression levels in the aorta of P. gingivalis-challenged mice were reduced in EGCG-treated mice. However, HO-1 mRNA levels were elevated by EGCG treatment, suggesting that EGCG, as a natural substance, inhibits P. gingivalis-induced atherosclerosis through anti-inflammatory and anti-oxidative effects.© 2012 Federation of European Microbiological Societies. Published by BlackwellPublishing Ltd. All rights reserved.

Study Type : Animal Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.