Abstract Title:

[Protective activity of different concentration of tea polyphenols and its major compound EGCG against whole body irradiation-induced injury in mice].

Abstract Source:

Zhongguo Zhong Yao Za Zhi. 2010 May;35(10):1328-31. PMID: 20707208

Abstract Author(s):

Shaolai Guo, Yuan Hu, Ping Liu, Yuyu Wang, Daihong Guo, Dongxiao Wang, Hongho Liao

Article Affiliation:

Department of Clinical Pharmacology, PLA General Hospital, Beijing 100853, China.

Abstract:

OBJECTIVE: To evaluate the different concentrate of tea polyphenols (TP) and its compound for irradiation-protection and investigate its mechanism.

METHOD: To evaluate the radioprotective activity, mice were exposed to whole body gamma irradiation. TP 80 and TP 50 (50, 10 mg x kg(-1)) and its major constituent epigallocatechin gallate (EGCG) (50, 10 mg x kg(-1)) were administered after irradiation to examine its inhibition against irradiation-induced injury.

RESULT: This study indicate that in comparison with non-irradiated controls, irradiation resulted in a significant reduction the spleen index (spleen weight/body weight 100), haematological parameters (RBC, WBC and PLT), activity of superoxide dismutase (SOD), and increase of malondialdehde (MDA) level in 28 days. Oral administration of TP (50 mg x kg(-1)) shown the best effect on reducing the irradiation-induced injury on mice studied, and showed a protective effect against irradiation-induced haematological parameters (RBC, WBC and PLT), the spleen index and MDA level significant reduction, and antioxidase activity (SOD) decrease.

CONCLUSION: The results suggest that TP 50 mg x kg(-1) and EGCG have in vivo antioxidant potential and radioprotective activity against whole body gamma irradiation in mice. It may be concluded that TP (50% EGCG) possess good irradiation-protective and antioxidant effect.

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