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Article Publish Status: FREE
Abstract Title:

Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge.

Abstract Source:

J Infect Dis. 2020 May 11 ;221(Supplement_4):S480-S492. PMID: 32037447

Abstract Author(s):

Michael K Lo, Jessica R Spengler, Lauren R H Krumpe, Stephen R Welch, Anasuya Chattopadhyay, Jessica R Harmon, JoAnn D Coleman-McCray, Florine E M Scholte, Anne L Hotard, Joshua L Fuqua, John K Rose, Stuart T Nichol, Kenneth E Palmer, Barry R O'Keefe, Christina F Spiropoulou

Article Affiliation:

Michael K Lo

Abstract:

Nipah virus (NiV) is a highly pathogenic zoonotic paramyxovirus that causes fatal encephalitis and respiratory disease in humans. There is currently no approved therapeutic for human use against NiV infection. Griffithsin (GRFT) is high-mannose oligosaccharide binding lectin that has shown in vivo broad-spectrum activity against viruses, including severe acute respiratory syndrome coronavirus, human immunodeficiency virus 1, hepatitis C virus, and Japanese encephalitis virus. In this study, we evaluated the in vitro antiviral activities of GRFT and its synthetic trimeric tandemer (3mG) against NiV and other viruses from 4 virus families. The 3mG had comparatively greater potency than GRFT against NiV due to its enhanced ability to block NiV glycoprotein-induced syncytia formation. Our initial in vivo prophylactic evaluation of an oxidation-resistant GRFT (Q-GRFT) showed significant protection against lethal NiV challenge in Syrian golden hamsters. Our results warrant further development of Q-GRFT and 3mG as potential NiV therapeutics.

Study Type : Animal Study

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