Article Publish Status: FREE
Abstract Title:

Growing up in a Bubble: Using Germ-Free Animals to Assess the Influence of the Gut Microbiota on Brain and Behaviour.

Abstract Source:

Int J Neuropsychopharmacol. 2016 Feb 23. Epub 2016 Feb 23. PMID: 26912607

Abstract Author(s):

Pauline Luczynski, Karen-Anne McVey Neufeld, Clara Seira Oriach, Gerard Clarke, Timothy G Dinan, John F Cryan

Article Affiliation:

Pauline Luczynski

Abstract:

There is a growing recognition of the importance of the commensal intestinal microbiota in the development and later function of the central nervous system (CNS). Research using germ-free mice (GF; mice raised without any exposure to microorganisms) has provided some of the most persuasive evidence for a role of these bacteria in gut-brain signalling. Key findings show that the microbiota is necessary for normal stress responsivity, anxiety-like behaviours, sociability, and cognition. Furthermore, the microbiota maintains CNS homeostasis by regulating immune function and blood brain barrier integrity. Studies have also found that the gut microbiota influences neurotransmitter, synaptic, neurotrophic signalling systems and neurogenesis. The principle advantage of the GF mouse model is in proof-of-principle studies and that a complete microbiota or defined consortiums of bacteria can be introduced at various developmental time points. However, a GF upbringing can induce permanent neurodevelopmental deficits that may deem the model unsuitable for specific scientific queries that do not involve early life microbial deficiency. As such, alternatives and complementary strategies to the GF model are warranted and include antibiotic treatment to create microbiota-deficient animals at distinct time points across the lifespan. Increasing our understanding of the impact of the gut microbiota on brain and behaviour has the potential to inform novel management strategies for stress-related gastrointestinal and neuropsychiatric disorders.

Study Type : Animal Study

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