Abstract Title:

The Gut-Brain Axis, Paving the Way to Brain Cancer.

Abstract Source:

Trends Cancer. 2019 Apr ;5(4):200-207. Epub 2019 Mar 16. PMID: 30961828

Abstract Author(s):

Ruty Mehrian-Shai, Juergen K V Reichardt, Curtis C Harris, Amos Toren

Article Affiliation:

Ruty Mehrian-Shai


The gut-brain axis formed by blood and lymphatic vessels paves the way for microbiota to impact the brain. Bacterial populations in the gut are a good candidate for a nongenetic factor contributing substantively to brain tumor development and to the success of therapy. Specifically, suppression of the immune system and induction of inflammation by microbiota sustain proliferative signaling, limit cell death, and induce angiogenesis as well as invasiveness. In addition, altered microbial metabolites and their levels could stimulate cell proliferation. We propose here a novel gear model connecting these complex interdisciplinary fields. Our model may impact mechanistic studies of brain cancer and better treatment outcomes through precision oncology.

Study Type : Review
Additional Links
Additional Keywords : Gut-brain Axis : CK(52) : AC(18)

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