Gut Microbiota-brain Axis. - GreenMedInfo Summary

n/a
Article Publish Status: FREE
Abstract Title:

Gut Microbiota-brain Axis.

Abstract Source:

Chin Med J (Engl). 2016 5th Oct;129(19):2373-80. PMID: 27647198

Abstract Author(s):

Hong-Xing Wang, Yu-Ping Wang

Article Affiliation:

Hong-Xing Wang

Abstract:

OBJECTIVE: To systematically review the updated information about the gut microbiota-brain axis.

DATA SOURCES: All articles about gut microbiota-brain axis published up to July 18, 2016, were identified through a literature search on PubMed, ScienceDirect, and Web of Science, with the keywords of"gut microbiota","gut-brain axis", and"neuroscience".

STUDY SELECTION: All relevant articles on gut microbiota and gut-brain axis were included and carefully reviewed, with no limitation of study design.

RESULTS: It is well-recognized that gut microbiota affects the brain's physiological, behavioral, and cognitive functions although its precise mechanism has not yet been fully understood. Gut microbiota-brain axis may include gut microbiota and their metabolic products, enteric nervous system, sympathetic and parasympathetic branches within the autonomic nervous system, neural-immune system, neuroendocrine system, and central nervous system. Moreover, there may be five communication routes between gut microbiota and brain, including the gut-brain's neural network, neuroendocrine-hypothalamic-pituitary-adrenal axis, gut immune system, some neurotransmitters and neural regulators synthesized by gut bacteria, and barrier paths including intestinal mucosal barrier and blood-brain barrier. The microbiome is used to define the composition and functional characteristics of gut microbiota, and metagenomics is an appropriate technique to characterize gut microbiota.

CONCLUSIONS: Gut microbiota-brain axis refers to a bidirectional information network between the gut microbiota and the brain, which may provide a new way to protect the brain in the near future.

Study Type : Review

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.