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Article Publish Status: FREE
Abstract Title:

Gut Microbiota Features in Young Children With Autism Spectrum Disorders.

Abstract Source:

Front Microbiol. 2018 ;9:3146. Epub 2018 Dec 19. PMID: 30619212

Abstract Author(s):

Lorena Coretti, Lorella Paparo, Maria Pia Riccio, Felice Amato, Mariella Cuomo, Alessandro Natale, Luca Borrelli, Giusi Corrado, Marika Comegna, Elisabetta Buommino, Giuseppe Castaldo, Carmela Bravaccio, Lorenzo Chiariotti, Roberto Berni Canani, Francesca Lembo

Article Affiliation:

Lorena Coretti

Abstract:

Proliferation and/or depletion of clusters of specific bacteria regulate intestinal functions and may interfere with neuro-immune communication and behavior in patients with autism spectrum disorder (ASD). Consistently, qualitative and quantitative alteration of bacterial metabolites may functionally affect ASD pathophysiology. Up to date, age-restricted cohort studies, that may potentially help to identify specific microbial signatures in ASD, are lacking. We investigated the gut microbiota (GM) structure and fecal short chain fatty acids (SCFAs) levels in a cohort of young children (2-4 years of age) with ASD, with respect to age-matched neurotypical healthy controls. Strong increase of Bacteroidetes and Proteobacteria and decrease of Actinobacteria was observed in these patients. Among the 91 OTUs whose relative abundance was altered in ASD patients, we observed a striking depletion of, one of the dominant bacteria in infant GM and, conversely, an increase of, a late colonizer of healthy human gut and a major butyrate producer. High levels ofwere associated to increase of fecal butyrate levels within normal range, and over representation of KEGG functions related to butyrate production in ASD patients. Here we report unbalance of GM structure with a shift in colonization by gut beneficial bacterial species in ASD patients as off early childhood.

Study Type : Human Study

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