Abstract Title:

Therapeutic effect of gypenoside on chronic liver injury and fibrosis induced by CCl4 in rats.

Abstract Source:

Am J Chin Med. 2000;28(2):175-85. PMID: 10999436

Abstract Author(s):

J C Chen, C C Tsai, L D Chen, H H Chen, W C Wang

Abstract:

Full Citation: "Gypenoside is a saponins extract derived from the Gynostemma pentaphyllum. The purpose of this study was to evaluate the hepatoprotective and antifibrotic potential of Gypenoside on chronic liver injury induced by CCl4 for 8 wks. The results indicated that the increase of SGOT, SGPT activities in CCl4 liver injury were significantly reduced by treatment with Gypenoside. It also elevated the A/G ratio. For the study of anti-fibrotic potential, Gypenoside reduced the collagen content by 33%. These phenomena were confirmed by pathologic observation; thinner bands of liver collagen were found. The results suggest that Gypenoside has hepatoprotective and anti-fibrotic activities."

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