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Abstract Title:

Lack of efficacy of Haemophilus b polysaccharide vaccine in Minnesota.

Abstract Source:

JAMA. 1988 Sep 9;260(10):1423-8. PMID: 3261350

Abstract Author(s):

M T Osterholm, J H Rambeck, K E White, J L Jacobs, L M Pierson, J D Neaton, C W Hedberg, K L MacDonald, D M Granoff

Article Affiliation:

Acute Disease Epidemiology Section, Minnesota Department of Health, Minneapolis 55440.

Abstract:

We evaluated the efficacy of Haemophilus b polysaccharide vaccine in children in Minnesota using a case-control study. The vaccine became available in Minnesota in August 1985. During the subsequent 28 months, 88 cases of invasive H influenzae type b disease were identified in children 24 to 71 months of age, the group targeted for vaccination. Of the 88 cases, 36 (41%) occurred in vaccinated children. Fifty-eight (33%) of 176 controls were vaccinated during a similar period. The vaccine's protective efficacy for children with any history of vaccination was -58% (95% confidence interval = -204% to 18%). The vaccine's protective efficacy for children who were most likely to be protected by vaccination was -55% (95% confidence interval = -238% to 29%). Our results indicate that vaccination with Haemophilus b polysaccharide vaccine had no effect in preventing H influenzae type b disease in Minnesota children.

Study Type : Human Study

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Sayer Ji
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