The efficacy and safety of Crataegus extract WS 1442 in patients with heart failure: the SPICE trial.
Eur J Heart Fail. 2008 Dec;10(12):1255-63. Epub 2008 Nov 18. PMID: 19019730
BACKGROUND: Crataegus preparations have been used for centuries especially in Europe. To date, no proper data on their efficacy and safety as an add-on-treatment are available. Therefore a large morbidity/mortality trial was performed. AIM: To investigate the efficacy and safety of an add-on treatment with Crataegus extract WS 1442 in patients with congestive heart failure. METHODS: In this randomised, double-blind, placebo-controlled multicenter study, adults with NYHA class II or III CHF and reduced left ventricular ejection fraction (LVEF