n/a
Abstract Title:

Hepatoprotective effects exerted by Poria Cocos polysaccharides against acetaminophen-induced liver injury in mice.

Abstract Source:

Int J Biol Macromol. 2018 Jul 15 ;114:137-142. Epub 2018 Mar 20. PMID: 29572139

Abstract Author(s):

Ka Wu, Jinlian Fan, Xiaoying Huang, Xinmou Wu, Chao Guo

Article Affiliation:

Ka Wu

Abstract:

Our study was to investigate the potential pharmacological activity of Poria Cocos polysaccharides (PCP) against acetaminophen (APAP)-induced liver injury in mice. PCP-dosed mice were used to conducting biochemical assays of serological liver enzyme (ALT), lactate dehydrogenase (LD), inflammatory cytokines (TNF-α, IL-6), and immunoassays for functional proteins in the livers. Consequently, APAP-exposed mice resulted in elevated levels of ALT, LD, TNF-α, IL-6 in sera. Interestingly, PCP-dosed mice exhibited reduced ALT, LD and inflammatory cytokines in blood. Inflammatory infiltration and cell death in liver tissue were decreased following by PCP treatments. Furthermore, immunofluorescence staining showed that AKR7A, c-Jun, Bcl-2-positive cells were increased in PCP-dosed livers in mice, while Bax-labeled cells were decreased. In addition, hepatocellular down-regulated NF-κBp65, IkBα expressions were observed dose-dependently in PCP-dosed livers in mice. Taken together, the current findings indicate that Poria Cocos polysaccharides exert pharmacological bioeffects against APAP-induced liver injury in mice, and the underlying molecular mechanism is associated to suppressing inflammatory response and apoptosis in liver cells.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.