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Article Publish Status: FREE
Abstract Title:

Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice.

Abstract Source:

Evid Based Complement Alternat Med. 2015 ;2015:418023. Epub 2015 Apr 16. PMID: 25960751

Abstract Author(s):

Lijun Hao, Yuxi Xie, Guikai Wu, Aibin Cheng, Xiaogang Liu, Rongjuan Zheng, Hong Huo, Junwei Zhang

Article Affiliation:

Lijun Hao

Abstract:

We investigated the effects of Hericium erinaceus (HEM) on liver injury induced by acute alcohol administration in mice. Mice received ethanol (5 g/kg BW) by gavage every 12 hrs for a total of 3 doses. HEM (200 mg/kg BW) was gavage before ethanol administration. Subsequent serum alanine aminotransferase (ALT) level, aspartate aminotransaminase (AST) level, Maleic dialdehyde (MDA) level, hepatic total antioxidant status (TAOS), andactivated nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) were determined by ELISA and immunohistochemistry, respectively. HEM administration markedly (P<0.05) decreased serum ALT, AST, and MDA levels. The hepatic histopathological observations showed that HEM had a relatively significant role in mice model, which had alcoholic liver damage. In conclusion, we observed that HEM (200 mg/kg BW) supplementation could restrain the hepatic damage caused by acute alcohol exposure.

Study Type : Animal Study

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