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Abstract Title:

Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine.

Abstract Source:

J Infect Dis. 2018 03 13 ;217(7):1055-1059. PMID: 29409017

Abstract Author(s):

Myron J Levin, Guang-Yun Cai, Katherine S Lee, Nadine G Rouphael, Aneesh K Mehta, Jennifer Canniff, Mark J Mulligan, Adriana Weinberg

Article Affiliation:

Myron J Levin

Abstract:

We studied the relationship between varicella-zoster virus (VZV) DNAemia and development of VZV-specific immunity after administration of live-attenuated zoster vaccine. VZV-DNAemia, detected by polymerase chain reaction (PCR), and VZV-specific effector (Teff) and memory (Tmem) T cells, was measured in 67 vaccinees. PCR was positive in 56% (9 direct, 28 nested) on day 1 and in 16% (1 direct, 10 nested) on day 14. Teff progressively increased in direct-PCR-positive vaccinees up to day 30, but Tmem did not. Conversely, Tmem, but not Teff, increased in direct-PCR-negative vaccinees on day 7. The kinetics of these immune responses and VZV DNAemia suggested that direct-PCR sample positive represented viremia.

Study Type : Human Study
Additional Links
Anti Therapeutic Actions : Vaccination: All : CK(6351) : AC(662)

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