Wigg. Attenuates Inflammatory Responses in Murine Microglia through the Nrf2/HO-1 and NF-B Signaling Pathways.
Am J Chin Med. 2020 Mar 5:1-18. Epub 2020 Mar 5. PMID: 32138531
As a long-established medicinal and edible homologous plant,Wigg. is widely distributed in Asia, Europe, and other parts of the world.is reported to exert a variety of biological and pharmacological activities, including anticancer, hepatoprotective, and anti-obesity effects. In this study, we evaluated the anti-inflammatory effects of ethanol extracts of(A-TOW) by examining the suppression of proinflammatory mediators in LPS-stimulated BV2 and mouse hippocampus. Furthermore, A-TOW also inhibited the nuclear translocation of nuclear factorB p65 caused by stimulation with LPS. In addition, A-TOW regulates heme oxygenase (HO)-1 expression through the nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) in BV2 cells. The effects of A-TOW on the over-expression of proinflammatory mediators were partially reversed by transfection of the cells with HO-1 siRNA. These findings suggest that the potent anti-inflammatory activity of, possibly through the regulation of Nrf2/HO-1 and NF-B signaling pathway.