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Abstract Title:

Hesperidin, a citrus flavonoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats.

Abstract Source:

Toxicol Mech Methods. 2019 Jul 25:1-32. Epub 2019 Jul 25. PMID: 31345080

Abstract Author(s):

Sundaram R, Nandhakumar E, Haseena Banu H

Article Affiliation:

Sundaram R

Abstract:

The present study was investigated the protective effect of hesperidin on carbohydrate metabolizing enzymes in streptozotocin induced diabetic rats. Hesperidin was administered to streptozotocin-induced (40 mg/kg b.w) diabetic rats at different dosages of (25, 50, 100 mg/kg b.w.) respectively for 30 days to evaluate its effect on fasting plasma glucose, insulin, glycosylated hemoglobin, hemoglobin and carbohydrate metabolic enzymes. The plasma glucose levels were significantly reduced in a dose-dependent manner in hesperdin treated group of rats when compared to the diabetic control rats. In addition, concomitant increase in hemoglobin and insulin levels and a decrease in glycosylated hemoglobin were observed in treated group of rats. The activities of the hepatic key enzymes of carbohydratemetabolism such as hexokinase and glucose-6-phosphate dehydrogenase were significantly increased whereas, glucose-6-phosphatase and fructose-1,6-bisphosphatase were significantly decreased. Furthermore, Hesperidin administration prevented the loss in body weight and improved the glycogen content inthe hepatic tissue of diabetic animals by reinstating the activities of glycogen synthase and glycogen phosphorylase. These results showed that hesperidin has potential antihyperglycemic activity in streptozotocin- induced diabetic rats. This was further supported by the histological studies of pancreas and liver.

Study Type : Animal Study

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