Abstract Title:

Hesperidin attenuates influenza A virus (H1N1)-induced lung injury in rats through its anti-inflammatory effect.

Abstract Source:

Antivir Ther. 2018 Apr 6. Epub 2018 Apr 6. PMID: 29623897

Abstract Author(s):

Zhen Ding, Gengyun Sun, Zhongming Zhu

Article Affiliation:

Zhen Ding


BACKGROUND: Influenza A viruses (IAV) can cause pandemics and are big threats to human health. Inflammation is the main pathological process in the lungs after IAV infection. We aimed at investigating whether hesperidin, a well-known anti-inflammatory material, could be effective in improving IAV-induced lung injury.

METHODS: We generated a rat model using H1N1 virus infection, and intraperitoneally injected with different doses of hesperidin for 5 days. Pulmonary function was analyzed. Local inflammatory state was profiled by immune cells and cytokines. Pulmonary microvascular endothelial cells were isolated from rats and used to test the effects of hesperidin in vitro.

RESULTS: Hesperidin showed efficacy in improving H1N1-induced impairment of pulmonary function a dose-dependent manner. Local numbers of immune cells and concentrations of cytokines were significantly limited by hesperidin. However, we found that hesperidin neither inhibited virus replication, nor rescued infected pulmonary microvascular endothelial cells. Rather, we observed that hesperidin reduced pro-inflammatory cytokine production by suppressing mitogen-activated protein kinases (MAPK) signaling pathways.

CONCLUSIONS: Hesperidin could alleviate H1N1-induced impairment of pulmonary function by inhibiting cytokine production in pulmonary microvascular endothelial cells through MAPK signaling pathways.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.